Picoplatin Potential Benefits Platinum drugs destroy cancer cells by binding to DNA. This causes damage that triggers apoptosis (programmed cell death) if the damage is too severe to be repaired by intracellular systems. However, currently available platinum therapies have significant shortcomings, including toxicities and drug resistance (both intrinsic and acquired) that limit their use. Picoplatin, which was designed to overcome platinum resistance associated with the treatment of solid tumors, has several potential benefits: Broadly applicable for treatment of solid tumors Demonstrated mechanism for use with new therapies May provide safer alternative to existing platinums Addresses unmet medical need by treating platinum-sensitive, -resistant and -refractory disease Large and growing market for platinum products