Picoplatin Picoplatin is a cytotoxic platinum compound in clinical development for the treatment of patients with solid tumors. It causes apoptosis (cell death) by binding to DNA and interfering with DNA replication and transcription. Intravenous Platinum-Based Chemotherapies Continue to be Widely Used to Treat Solid Tumors Source: IntrinsiQ (2007): Average Projected Patients – Drug Diag LOT Yearly - 2007 data (oxaliplatin, cisplatin, carboplatin) and LEK consulting Picoplatin is a new generation platinum chemotherapy agent that has an improved safety profile compared to existing platinum-based chemotherapeutics and was designed to overcome platinum resistance. Picoplatin has been evaluated in more than 750 patients and has demonstrated activity in multiple indications with no evidence of significant kidney, nerve toxicity or hearing loss.